Begin by preheating your oven to 425°F (220°C) and prepare a baking sheet with parchment paper for easy cleanup.
Rinse and pat the tilapia fillets dry with paper towels, then set aside to ensure a crispier crust.
In a bowl, mix together the Panko breadcrumbs, grated Parmesan cheese, and garlic powder. This blend will create a flavorful topping for your fish.
Brush each tilapia fillet with the melted butter, ensuring to cover the top surface evenly with a nice layer.
Dredge the buttered fillets in the breadcrumb mixture, pressing down gently to ensure the topping adheres well.
Transfer the crusted fillets to the baking sheet, allowing a little space between each piece for even cooking.
Bake in the preheated oven for about 12-15 minutes, or until the fish becomes opaque, flakes easily with a fork, and the crust is golden and crisp.